The scientists from Imperial College London, led a study creating a world map of human metabolism in which they analyzed urine samples from 4,630 people in the United States, Britain, Japan and China.

They discovered that what affects peoples' blood pressure may be based on what they eat and their gut bacteria rather than a genetic factor.

Lead researcher Professor Jeremy Nicholson says it is possible to geographically map people according to their metabolic patterns.

The research revealed that adults in the UK and U.S. which have similar levels of high blood pressure and heart disease, have almost identical 'metabolic fingerprints', possibly reflecting similar lifestyles.

However adults from Japan and China have similar genetic profiles but very different metabolites, both from each other and from British and Americans and differences were also seen between regions within individual countries - north and south China and the north and south of the U.S.

Dr. Nicholson says the patterns do not seem to follow genetics, but have more to do with diet and lifestyle and also gut microorganisms.

Nicholson says bacteria in the intestines and colon help digest and break down food and recent research has suggested that the relationship in humans with their gut bacteria is a symbiotic one.

The scientists say some of the compounds they release have drug-like effects, and they examined breakdown products in human urine, called metabolites, in order to see if there were any links with heart disease.

The team identified four compounds which can be linked with blood pressure differences, the best-known of which is high salt intake.

Another was a compound called formic acid or formate which the researchers suspect may be involved in processing chloride from salt in the kidneys.

An amino acid called alanine was also found in people with higher blood pressure and this is thought to be linked to a diet rich in meat and other animal products.

Hippurate, another by-product of gut bacteria, was found in people with lower blood pressure who drink less and eat more fibre in their diet.

It is estimated that 1 billion people worldwide have high blood pressure, which is defined as a reading of 140/90 or higher.

High blood pressure or hypertension, is a major cause of stroke, heart disease and kidney failure and experts say a diet rich in vegetables and certain minerals along with regular exercise can help control high blood pressure.

The researchers say 'metabolic fingerprints' which are left behind after the breakdown of food and chemicals in the body, may well offer vital clues to the causes of disease.

Researcher Professor Paul Elliott, from the Department of Epidemiology and Public Health at Imperial College, says while a person cannot alter their DNA, they can change their metabolic profile by changing their diet and lifestyle.

The researchers hope their findings may lead to the development of new drugs to fight high blood pressure or possibly non-drug therapies.

The research is published in the current issue of the journal Nature.

Tag Cloud

Order Adalat Without Prescription
Order Aldactone Without Prescription
Order Altace Without Prescription
Order Atenolol Without Prescription
Order Avalide Without Prescription
Order Avapro Without Prescription
Order Azor Without Prescription
Order Benicar Without Prescription
Order Betapace Without Prescription
Order Caduet Without Prescription
Order Captopril Without Prescription
Order Cardura Without Prescription
Order Clonidine Without Prescription
Order Co-Diovan Without Prescription
Order Cordarone Without Prescription
Order Coreg Without Prescription
Order Coversyl Without Prescription
Order Cozaar Without Prescription
Order Diltiazem HCL Without Prescription
Order Diovan Without Prescription
Order Hydrochlorothiazide Without Prescription
Order Hytrin Without Prescription
Order Hyzaar Without Prescription
Order Inderal Without Prescription
Order Isosorbide Mononitrate Without Prescription
Order Lanoxin Without Prescription
Order Lasix Without Prescription
Order Lipitor Without Prescription
Order Lotensin Without Prescription
Order Lotrel Without Prescription
Order Lozol Without Prescription
Order Micardis Without Prescription
Order Minipress Without Prescription
Order Nebivolol Without Prescription
Order Norvasc Without Prescription
Order Plavix Without Prescription
Order Pletal Without Prescription
Order Prinivil Without Prescription
Order Rosulip-F Without Prescription
Order Toprol XL Without Prescription
Order Torsemide Without Prescription
Order Trandate Without Prescription
Order Trental Without Prescription
Order Triamterene Without Prescription
Order Tricor Without Prescription
Order Vasotec Without Prescription
Order Vastarel Without Prescription
Order Verapamil Without Prescription
Order Zebeta Without Prescription
Order Zestoretic Without Prescription